Sciences indexed since 1998 submit story | join | login   view all biology business chemistry engineering geography health mathematics society   all     desmoid tumors: clinical features and treatment options for advanced disease submitted by trontein 1 year and 4 months ago desmoid tumors describe a rare monoclonal, fibroblastic proliferation characterized by a variable and often unpredictable clinical course. viagra coupon Although histologically benign, desmoids are locally invasive and associated with a high local recurrence rate, but lack metastatic potential. On the molecular level, desmoids are characterized by mutations in the β-catenin gene, ctnnb1, or the adenomatous polyposis coli gene, apc. viagra canada safety Proof of a ctnnb1 mutation may be useful when the pathological differential diagnosis is difficult and location might be predictive for disease recurrence. Many issues regarding the optimal treatment of patients with desmoids remain controversial; however, surgery is the therapeutic mainstay, except if mutilating and associated with considerable function loss. Postoperative radiotherapy reduces the local recurrence rate, in cases of involved surgical margins. Because of the heterogeneity of the biological behavior of desmoids, including long periods of stable disease or even spontaneous regression, treatment needs to be individualized to optimize local tumor control and preserve patients' quality of life. Therefore, the application of a multidisciplinary assessment with multimodality treatment forms the basis of care for these patients. cheap viagra online Watchful waiting may be the most appropriate management in selected asymptomatic patients. Patients with desmoids located at the mesentery or in the head and neck region could present with life-threatening complications and often need more aggressive treatment. order viagra This review describes treatment options and management strategies for patients with desmoid tumors with a focus on advanced disease. 1 dig(s) dig it bury topic: oncology comments (0) who dugg this story? where to order viagra Email this link add your comment please login or signup to leave a comment related stories fibrodysplasia ossificans progressiva: clinical and genetic aspects submitted by cristofe 4 months ago fibrodysplasia ossificans progressiva (fop) is a severely disabling heritable disorder of connective tissue characterized by congenital malformations of the great toes and progressive heterotopic ossification that forms qualitatively normal bone in characteristic extraskeletal sites. brand viagra cheap The worldwid... buy viagra online   1 dig(s) dig it bury topic: health positron emission tomography in patients with aggressive fibromatosis/desmoid tumours undergoing therapy with imatinib submitted by miguekyan 2 years and 3 months ago we used 18f-fdg pet to evaluate the fdg uptake in patients with aggressive fibromatosis (af, also known as desmoid tumours) undergoing therapy with imatinib (imatinib me. viagra canada viagra viagra price difference

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